Interactions between malaria parasites and avian hosts

I use dual RNA-sequencing of birds infected with malaria parasites. Because I'm sequencing the blood, this allows me to analyse not only the transcriptome of the host, but also the transcriptome of the malaria parasite simultaneously. This gives unprecedented opportunity to evaluate real-time interactions between hosts and parasites. 

Publications and manuscripts in this project:

  • Videvall et al. 2015. The Avian Transcriptome Response to Malaria Infection. Molecular Biology and Evolution.
  • Bensch et al. 2016. The genome of Haemoproteus tartakovskyi and its relationship to human malaria parasites. Genome Biology and Evolution.
  • Videvall et al. 2017. The transcriptome of the avian malaria parasite Plasmodium ashfordi displays host-specific gene expression. Molecular Ecology.
  • Hellgren et al. In prep. De-novo synthesis of thiamine (vitamin B1) in malaria parasites. 

The gut microbiome's influence on avian fitness and survival

Ostrich chicks can experience dramatic mortality rates due to disease. The development of a healthy gut microbiome seems to be a crucial step in the first three months of an ostrich.

I use 16S-seq to characterize the gut microbiome over time and associate its various components with growth and survival.


Manuscripts in this project:

  • Strandh et al. In prep. Evaluation of a DirectPCR method in relation to 16S-sequencing
  • Videvall et al. In prep. Gut microbiome methods paper
  • Videvall et al. In prep. Longitudinal study of ostrich chicks' gut microbiome, and its relationship to growth and survival

Other research projects

In addition to my PhD work, I'll also mention briefly some of the collaborating projects I'm involved in:

  • Transcriptome differences between urban and rural birds - (Watson et al. 2017)
  • Dual RNA-seq of mosquitoes infected with avian malaria parasites 
  • Expression of MHC genes using different techniques
  • Great Reed Warbler genome assembly
  • Sex-specific avian gene expression using transcriptomics

Previous research

  • Transcriptomics of outcrossing Arabidopsis lyrata - (Videvall et al. 2016)
  • Transcriptomics of the hessian fly - (Andersson et al. 2014)
  • Molecular identification of blood meals in biting midges - (Pettersson et al. 2013)
  • Monitoring butterflies using grid-based sampling - (Videvall et al. 2016)

Future research?

Interested in collaborating? Need someone with bioinformatic knowledge to assist with analyses? Contact me with any inquiries.

All figures on this page, except the malaria phylogeny, have been produced by myself. Several are still unpublished so please ask for permission if you intend to use any of them.