Interactions between malaria parasites and avian hosts
I use dual RNA-sequencing of birds infected with malaria parasites. Because I'm sequencing the blood, this allows me to analyse not only the transcriptome of the host, but also the transcriptome of the parasite simultaneously. This gives unprecedented opportunity to evaluate real-time interactions between hosts and parasites.
Publications and manuscripts in this project:
- Videvall et al. 2015. The Avian Transcriptome Response to Malaria Infection. Molecular Biology and Evolution.
- Bensch et al. 2016. The genome of Haemoproteus tartakovskyi and its relationship to human malaria parasites. Genome Biology and Evolution.
- Videvall et al. 2017. The transcriptome of the avian malaria parasite Plasmodium ashfordi displays host-specific gene expression. Molecular Ecology.
- Hellgren et al. De-novo synthesis of thiamine (vitamin B1) in malaria parasites. Under Review.
- Videvall et al. Differences in avian transcriptome responses over the course of infection to a virulent and a non-virulent lineage of Plasmodium. In prep.
- Videvall et al. Transcriptome analyses of both a virulent and a non-virulent lineage of Plasmodium during infection in birds. In prep.
The gut microbiome's influence on avian fitness and survival
Ostrich chicks can experience dramatic mortality rates due to disease. The development of a healthy gut microbiome seems to be a crucial step in the first three months of an ostrich.
I use 16S rRNA Illumina MiSeq to characterize the gut microbiome over time and associate its various components with growth and survival.
Manuscripts in this project:
- Videvall et al. 2017. Measuring the gut microbiome in birds: comparison of faecal and cloacal sampling. bioRxiv. doi: https://doi.org/10.1101/160564
- Videvall et al. Evaluation of a DirectPCR method in relation to 16S-sequencing. In prep.
- Videvall et al. Longitudinal study of the gut microbiome of ostrich chicks, and its relationship to growth and survival. In prep.
- Videvall et al. Effects of coprophagy on the gut microbiome of juvenile ostriches. In prep.
Other research projects
In addition to my PhD work, I'll also mention briefly some of the collaborating projects I'm involved in:
- Transcriptome differences between urban and rural birds - (Watson et al. 2017)
- Dual RNA-seq of mosquitoes infected with avian malaria parasites
- Expression of MHC genes using different techniques
- Great Reed Warbler genome assembly
- Sex-specific gene expression in birds using RNA-sequencing
- Transcriptomics of outcrossing Arabidopsis lyrata - (Videvall et al. 2016)
- Transcriptomics of the hessian fly - (Andersson et al. 2014)
- Molecular identification of blood meals in biting midges - (Pettersson et al. 2013)
- Monitoring butterflies using grid-based sampling - (Videvall et al. 2016)
Interested in collaborating? Need someone with bioinformatic knowledge to assist with analyses? Contact me with any inquiries.
All figures on this page have been produced by me. Some might still be unpublished so please do not use them without asking for permission.